When assessing the turbulence on the financial markets of the last few years, one of the main outcomes for investors was a heightened awareness of cash and security arrangements. In particular, it has become en vogue among asset owners to ask their custodians to segregate client assets from the custodians’ proprietary assets. While asset segregation has thus become a global topic, the legal effects of such segregation may differ from jurisdiction to jurisdiction. This article provides a summary overview of the patterns of asset segregation and their (possible) effects under Swiss law.