On 10 March 2022, Roche Holdings, Inc. successfully completed its issuance of USD 5 billion in aggregate principal amount of senior notes, consisting of USD 1.25 billion 1.882% Notes due 2024, USD 1 billion 2.132% Notes due 2025, USD 1,25 billion 2.314% Notes due 2027, USD 750 million Floating Rate Notes due 2023, and USD 750 million Floating Rate Notes due 2025. The notes are irrevocably and unconditionally guaranteed by Roche Holding Ltd.